Fascinating Aspects of Glycobiology—Part 7 (COVID-19)

Larry A. Law

Saying the word COVID-19 still gets my blog articles tagged by social media and sent to spam folders when I include them in the eZine. It's been five years, but the entrenched medical system still does not want the truths to come out concerning the fake pandemic. I have published 125 articles since November 2019 when the medically-induced fearmongering began. Fortunately, a positive side-effect of the panic resulted in the public learning more about glycobiology than they had ever known before. 

Glycobiology and COVID-19 

As shown in the picture above, some of the areas specifically related to glycobiology and COVID-19 included: the SARS-CoV-2 spike protein (a glycoprotein), cell receptors (ACE2 receptors—also a glycoprotein), the experimental mRNA vaccine which forced cells to create a synthetic spike glycoprotein, how chronic disease (comorbidities) weakens the immune system, and the glycobiology behind hydroxychloroquine. 
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​Dr. Fauci Needs to be Held Accountable

It was unconscionable that the National Institutes of Health (NIH), Centers for Disease Control (CDC), and the American Medical Association (AMA) discouraged and actually prohibited early treatment of patients suffering with COVID-19. Instead, they forced hospitals to send people home without any treatment and told them to come back when their lips turned blue. Then, they put them on ventilators and most of them died at that stage. Administration of hydroxychloroquine and ivermectin would have prevented millions of deaths and hospitalizations. But because federal law stated that an experimental vaccine (representing billions of dollars) could not be developed if there was a proven therapeutic, the medical system washed their hands of early treatment and condemned countless individuals to their death. Doctors who tested these therapeutic treatments successfully and tried to get the word out were ridiculed, banished, and fired from their jobs. The medical system closed ranks and refused to open the door to scientific discussion. A vaccine was their only approved solution. The truth about the science behind COVID-19 vaccines is slowly coming out. 

Authors published a study on June 3, 2024 in the BMJ Public Health concluding that excess death data from 47 countries in the Western world show that excess mortality has remained high for the last three consecutive years—despite COVID-19 lockdown measures and COVID-19 vaccines. Researchers called on government leaders to "thoroughly investigate underlying causes of persistent excess mortality." The Telegraph, a prominent mainstream UK newspaper, ran a front-page article the next day with the headline, "COVID vaccines may have helped fuel rise in excess deaths."

A great new movie documenting issues surrounding the COVID pandemic is called Unsafe and Ineffective. You can watch it for free by clicking here and putting in your name and email. 

Hydroxychloroquine Example of Glycobiology

On August 4, 2020 I published an article on how glycobiology explained why hydroxychloroquine worked. This was before a vaccine was developed and it was only 6 months after the gain-of-function virus had escaped from Wuhan, China. I've included two excerpts from that article because it shows how vitally important understanding the power of glycobiology is and how vital it was to fighting the COVID-19 virus. 

Zinc Ionophore 

First, hydroxychloroquine (HCQ) acts as a zinc ionophore (carrier) on the glycocalyx of the cells. Zinc is a crucial mineral in fighting viruses. It interrupts the ability of the virus to replicate. The zinc ion has 2 positive charges (red dot in picture below). The cell membrane has no charge, so that the zinc ion cannot cross through that barrier by itself. HCQ is used by the cell and becomes embedded within the cell membrane (glycocalyx) as an ionophore (green revolving door in picture below). This carrier can capture a zinc ion floating outside the cell. The carrier then encapsulates the zinc ion, allowing it to keep its charge. It transfers the zinc from outside the cell to the inside, where it is released. The positively charged zinc ion can now interact with the virus's RdRp enzyme, independent of HCQ, and alter it so it cannot do its job. In this way, replication of the virus ceases because of the disruption of this important viral metabolic pathway. The virus cannot reproduce inside the cell. ​

Glycosylation

Secondly, HCQ alters the glycosylation of the ACE2 receptor which diminishes the ability of the virus to attach to the cell. This is actually a good thing! If the virus cannot attach to a healthy cell, then it can't infect it. There are nearly a million receptors on every cell. The ACE2 (Angiotensin-Converting Enzyme 2) receptor is a series of amino acids and glycans (sugars) built within the Golgi Apparatus (GA) and Endoplasmic Reticulum (ER) of human cells. When assembled, the ACE2 glycoprotein receptor is carried to and installed on the glycocalyx (the outer membrane of the cell). However, HCQ interferes with the glycosylation of the last sugar molecule (glucose) at the end of this receptor's creation process. So, these ACE2 receptors, which have hundreds of sugars, are missing that one last sugar molecule. One would think that such a small difference wouldn't amount to much, but losing that one molecule is enough to affect the binding ability of the spike glycoprotein on the virus. The affinity of binding is not strong enough to allow the virus to adhere to the cell. In other words, the virus slips off the binding site. If there is no adhesion, then there cannot be viral attachment. If the COVID-19 virus can't attach, then there is no coronavirus infection. End of pandemic!

These are just two out of at least 5 ways that HCQ blocks viruses from replicating in human cells. And it isn't  just COVID-19, but flu, Ebola virus (pictured below), Zika... you name it! This is why the entire medical system needs to be revamped to focus on strengthening immune systems so people do not die needlessly.