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Glycobiology Sugars and Influenza (Flu)

3/31/2020

10 Comments

 

Larry A. Law

Glycobiology involves the study of eight sugars within the human body. These sugars (glycans) form antenna structures called cell receptors on the surface of all cells. One of the most important sugars is called sialic acid. It is often located at the end of these antennas. Sialic acid is made from another sugar called mannose within the body. The influenza virus attaches to human cells via sialic acid. The geometry of the sugar connection determines whether flu from animals can infect humans. The current coronavirus pandemic thought to originate from bats is a good example. Avian (bird) flu prefers to bind to sialic acid which is attached to galactose via an alpha (2,3) link (the second carbon in sialic acid is linked to the third carbon in galactose). Human flu prefers an alpha (2,6) link (sixth carbon in galactose). 
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Studies of flu pandemics from 1918, 1957, 1968, and 2009 suggest these viruses successfully mutated from the alpha (2,3) link (animal) to the alpha (2,6) link (human). The 1918 flu resulted in 35 million deaths. This was more deaths than from World War I and World War II combined! Understanding glycobiology and how glycans are employed on cells is critical for prevention efforts and disease treatments involving drugs or vaccines.
These sugars studied  in the science of glycobiology have existed in nature since the dawn of time. Our body’s immune systems are synchronized to the tiniest variation in the geometry of cell-surface, sugar-structures. Glycobiology represents the frontier for understanding disease and metabolic processes in the body.

A good example of how these sugars are being recognized involves the Centers for Disease Control (CDC). The CDC comes up with names for different influenza using a labeling system focused on these sugars. Let's consider the H5N1 label. H stands for hemagglutinin which is a protein that binds/attaches the virus to sialic acid receptors on the surface of human cells. This attachment allows the virus to enter the targeted cell. N stands for neuraminidase which is the enzyme that cleaves or cuts the connection to sialic acid. When the newly formed virus emerges out of the infected cell it is attached to a cell receptor. The enzyme cleaves the sialic acid attachment which frees the virus to travel to another non-infected cell and begin the process all over again. Epithelial cells of swine trachea produce both alpha (2,3) and alpha (2,6) linked sialic acids. It is theorized that avian flu with the alpha (2,3) link is morphed into a human binding alpha (2,6) linkage within swine.  The swine serve as the mixing vessel for new pandemic type viruses. Because of the importance of this type of receptor for flu, the CDC actually tracks this specific glycobiolody linkage on these sugars as it watches for the next potential epidemic.
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While there is not much we can do to avoid a pandemic virus, the best defense is still a strong immune system. If you would like to see the class where we overview critical sugar nutrients and how they strengthen our immune system click here.
10 Comments
Roos
3/31/2020 06:00:12 am

Thank you for sharing this valuable information with us in these difficult times. Especially for your family. I'll send light and love from the Netherlands to you!

Reply
Larry Law
4/15/2020 04:50:58 pm

Thank you Roos!

Reply
Jason Dyck
3/31/2020 12:24:06 pm

Great article, Larry. The part about swine having both the alpha (2,3) and the alpha (2,6) links would lend credence to the command from God in the Torah that pigs be considered unclean and should be kept out of our regular diet.

God knew what He made. He knew what He wanted. He told us what we could and couldn't eat for our best health, and then left the decision up to us.

Jews and Muslims don't eat pork products. They're some of the healthiest cultures on earth. Once the transition has been made, though, even Jews and Muslims would be at risk.

Thanks for also making the connection that even though the influenza can get in through the glyconutrient "forest" or "beard", the best defense is still the intake of sufficient or even extra glyconutrients because the body's cells have the innate God-designed ability to heal itself. Yet, as Angie so eloquently and tearfully revealed in today's opening remarks, it is the way of life, the circle of life, that we will also die. My heart and prayers go out to you and your children as you watch your dear daughter leave our side. Know this, that you will see her again in heaven. I can't imagine any of our children leaving before we do. I appreciate Angie's words of how the alternatives to the medical paradigm seem to have allowed her to go peace-ably and peacefully. God bless.

Reply
Angie Law
4/7/2020 07:27:36 pm

Thank you Jason...truly appreciate your kind words. There is no question our daughter was spared so much misery due to all she did. Just wish we had had more time with her...prevention is the best help which begins many years before a diagnosis. And, of course if she had known before the cancer was already so advanced that would have given us more time. But, there are no regrets as she did an amazing job and her life and family were blessed throughout. Hugs and Blessings, Angie

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Joan No,an link
3/31/2020 04:30:22 pm

My husband and I were brought to tears hearing from Angie about her beautiful daughter passing today. We can not imagine how it feels.
God Bless you all at this very difficult time
Joan Nolan

Reply
Angela Law
4/7/2020 07:36:00 pm

Thank you so much Joan...we so appreciate the outpouring of love...we're taking it one day at a time...thank you.

Reply
Yvonne Morrison
3/31/2020 09:09:00 pm

Larry thanks for the valuable article.

My deepest heartfelt sympathy for your lost. May all the encouragements, love and kind guidance that you both poured out on us through these years return to comfort you and your family at this sad time. My prayers are sent to you at this difficult time. May the peace of El-Shalom be with you!

Reply
Angela Law
4/7/2020 07:37:51 pm

Thank you Yvonne...we truly appreciate the love and support we have received. We thank you for your prayers...

Reply
Jason Dyck
4/1/2020 10:19:43 pm

May the Lord's great. amazing, and wonderful compassionate be with your family in this time of grief. My prayers and thoughts are with you. I can empathize because our brother-in-law's funeral was a mere two weeks ago. He also died of cancer.

Reply
Angela Law
4/7/2020 07:44:19 pm

Thank you Jason...we are so sorry to hear about your brother-in-law also. It's such a hard thing to be without those we love. Our solace comes from knowing we will be together again--it gives us more reason to live good lives to merit a heaven with her! Blessings to you and your family with your terrible loss...so very sorry.

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